 |
Article dans une revue
[Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].
Abstract : A mitochondrial dysfunction has been suggested to explain chronic renal toxicity observed in ciclosporine A therapy. Our study has investigated whether trimetazidine allows inhibition of mitochondrial alteration induced by ciclosporine A. Oxidative phosphorylation was measured by polarography, calcium fluxes by a specific calcium electrode and the mitochondrial swelling by determination of the optical density at 520 nm, using a spectrophotometer. The ciclosporine A effect on the respiratory control was fully inhibited by trimetazidine (EC50 5.10 x 10(-7) M; Emax 11 per cent). Trimetazidine also inhibited the ciclosporine effects on calcium fluxes, i.e. calcium accumulation into the matrix and delay of efflux. Trimetazidine allows a decrease of mitochondrial dysfunction induced by ciclosporine A.
https://hal-enpc.archives-ouvertes.fr/hal-02268288
Contributeur : Christophe Morin <>
Soumis le : mardi 20 août 2019 - 16:23:11
Dernière modification le : mardi 6 octobre 2020 - 03:09:36
Contributeur : Christophe Morin <>
Soumis le : mardi 20 août 2019 - 16:23:11
Dernière modification le : mardi 6 octobre 2020 - 03:09:36