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[Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].

Abstract : A mitochondrial dysfunction has been suggested to explain chronic renal toxicity observed in ciclosporine A therapy. Our study has investigated whether trimetazidine allows inhibition of mitochondrial alteration induced by ciclosporine A. Oxidative phosphorylation was measured by polarography, calcium fluxes by a specific calcium electrode and the mitochondrial swelling by determination of the optical density at 520 nm, using a spectrophotometer. The ciclosporine A effect on the respiratory control was fully inhibited by trimetazidine (EC50 5.10 x 10(-7) M; Emax 11 per cent). Trimetazidine also inhibited the ciclosporine effects on calcium fluxes, i.e. calcium accumulation into the matrix and delay of efflux. Trimetazidine allows a decrease of mitochondrial dysfunction induced by ciclosporine A.
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https://hal-enpc.archives-ouvertes.fr/hal-02268288
Contributeur : Christophe Morin <>
Soumis le : mardi 20 août 2019 - 16:23:11
Dernière modification le : mardi 6 octobre 2020 - 03:09:36

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  • HAL Id : hal-02268288, version 1
  • PUBMED : 11806297

Citation

C. Simon, Christophe Morin, B Bruguerolle, J. Tillement. [Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].. Thérapie, EDP Sciences, 1970, 56 (5), pp.583-7. ⟨hal-02268288⟩

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