Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells

Mathieu Adjemout (1, 2) , Bruno Pouvelle (1, 2) , Fatou Thiam (3) , Alassane Thiam (4) , Magali Torres (1, 2) , Samia Nisar (1, 2) , Babacar Mbengue (3) , Alioune Dieye (3) , Pascal Rihet (1, 2) , Sandrine Marquet (1, 2)

1 TAGC - Theories and Approaches of Genomic Complexity
2 MarMaRa - Institut Marseille Maladies Rares
3 UCAD - Université Cheikh Anta Diop de Dakar [Sénégal]
4 Institut Pasteur de Dakar

Mots clés: PIEZO1; ATP2B4; SNP; Malaria; functional genomics; Calcium

Domaines: Médecine humaine et pathologie; Biochimie, Biologie Moléculaire

Mathieu Adjemout, Bruno Pouvelle, Fatou Thiam, Alassane Thiam, Magali Torres, et al.. Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells. Genes & Diseases, 2023, 10 (6), pp.2210-2214. ⟨10.1016/j.gendis.2023.02.029⟩. ⟨hal-04179608⟩