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Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways

Abstract : Background: Base excision repair (BER) is the major pathway for repair of single oxidized nucleobases. Results: Bifunctional DNA glycosylases and AP endonucleases are able to remove cross-linked guanine in guanine(C8)-thymine(N3) intrastrand cross-links. Conclusion: BER pathways can repair the intrastrand cross-links. Significance: Oxidatively generated intrastrand cross-linked DNA lesions can be repaired in HeLa cell extracts not only by nucleotide excision repair, but also by multiple BER pathways.
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https://hal.archives-ouvertes.fr/hal-03419414
Contributor : Ibtissam TALHAOUI Connect in order to contact the contributor
Submitted on : Monday, November 8, 2021 - 2:31:48 PM
Last modification on : Monday, August 8, 2022 - 5:12:05 PM
Long-term archiving on: : Wednesday, February 9, 2022 - 7:52:32 PM

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Ibtissam Talhaoui, Vladimir Shafirovich, Zhi Liu, Christine Saint-Pierre, Zhiger Akishev, et al.. Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290, pp.14610 - 14617. ⟨10.1074/jbc.m115.647487⟩. ⟨hal-03419414⟩

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