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Gustave Roussy |  |
Journal articles
Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways
Abstract : Background: Base excision repair (BER) is the major pathway for repair of single oxidized nucleobases. Results: Bifunctional DNA glycosylases and AP endonucleases are able to remove cross-linked guanine in guanine(C8)-thymine(N3) intrastrand cross-links. Conclusion: BER pathways can repair the intrastrand cross-links. Significance: Oxidatively generated intrastrand cross-linked DNA lesions can be repaired in HeLa cell extracts not only by nucleotide excision repair, but also by multiple BER pathways.
https://hal.archives-ouvertes.fr/hal-03419414
Contributor : Ibtissam Talhaoui Connect in order to contact the contributor
Submitted on : Monday, November 8, 2021 - 2:31:48 PM
Last modification on : Wednesday, December 15, 2021 - 10:00:59 AM
Contributor : Ibtissam Talhaoui Connect in order to contact the contributor
Submitted on : Monday, November 8, 2021 - 2:31:48 PM
Last modification on : Wednesday, December 15, 2021 - 10:00:59 AM
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