Microgels of silylated HPMC as a multimodal system for drug co-encapsulation

Mohamed Zayed (1) , Corine Tourné-Péteilh (1) , Michel Ramonda (2) , Gildas Réthoré (3) , Pierre Weiss (3) , Jean Martinez (4) , Gilles Subra (4) , Ahmad Mehdi (1) , Jean-Marie Devoisselle (1) , Philippe P. Legrand (1)

1 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 Centrale de Technologie en Micro et Nanoélectronique CTM-­LMCP
3 RMeS - Regenerative Medicine and Skeleton
4 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Combined therapy is a global strategy developed to prevent drug resistance in cancer and infectious diseases. In this field, there is a need of multifunctional drug delivery systems able to co-encapsulate small drug molecules, peptides, proteins, associated to targeting functions, nanoparticles. Silylated hydrogels are alkoxysilane hybrid polymers that can be engaged in a , providing chemical cross linking in physiological conditions, and functionalized biocompatible hybrid materials. In the present work, microgels were prepared with silylated (hydroxypropyl)methyl cellulose (Si-HPMC) that was chemically cross linked in soft conditions of pH and temperature. They were *Manuscript revised version Click here to view linked References

Domaines: Pharmacie galénique; Matériaux; Polymères

Mohamed Zayed, Corine Tourné-Péteilh, Michel Ramonda, Gildas Réthoré, Pierre Weiss, et al.. Microgels of silylated HPMC as a multimodal system for drug co-encapsulation. International Journal of Pharmaceutics, 2017, 532 (2), pp.790 - 801. ⟨10.1016/j.ijpharm.2017.07.074⟩. ⟨hal-01620498⟩