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Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite

Sarah Séité 1 Mark Harrison 2 David Sillam-Dussès 3 Roland Lupoli 1 Tom van Dooren 1, 4 Alain Robert 3 Laure-Anne Poissonnier 5 Arnaud Lemainque 6 David Renault 7, 8 Sébastien Acket 9 Muriel Andrieu 10 José Viscarra 11 Hei Sook Sul 11 Z. Wilhelm de Beer 5 Erich Bornberg-Bauer 2 Mireille Vasseur-Cognet 1
1 iEES Paris - Institut d'écologie et des sciences de l'environnement de Paris
2 WWU - Westfälische Wilhelms-Universität Münster = University of Münster
3 LEEC - Laboratoire d'Ethologie Expérimentale et Comparée
4 Naturalis Biodiversity Center [Leiden]
5 University of Pretoria [South Africa]
6 JACOB - Institut de Biologie François JACOB
7 ECOBIO - Ecosystèmes, biodiversité, évolution [Rennes]
8 IUF - Institut Universitaire de France
9 GEC UPJV - Génie Enzymatique et Cellulaire. Reconnaissance Moléculaire et Catalyse - UMR CNRS 7025
10 IC UM3 (UMR 8104 / U1016) - Institut Cochin
11 University of California
Abstract : Kings and queens of eusocial termites can live for decades, while queens sustain a nearly maximal fertility. To investigate the molecular mechanisms underlying their long lifespan, we carried out transcriptomics, lipidomics and metabolomics in Macrotermes natalensis on sterile short-lived workers, long-lived kings and five stages spanning twenty years of adult queen maturation. Reproductives share gene expression differences from workers in agreement with a reduction of several aging-related processes, involving upregulation of DNA damage repair and mitochondrial functions. Anti-oxidant gene expression is downregulated, while peroxidability of membranes in queens decreases. Against expectations, we observed an upregulated gene expression in fat bodies of reproductives of several components of the IIS pathway, including an insulin-like peptide, Ilp9. This pattern does not lead to deleterious fat storage in physogastric queens, while simple sugars dominate in their hemolymph and large amounts of resources are allocated towards oogenesis. Our findings support the notion that all processes causing aging need to be addressed simultaneously in order to prevent it.
Keywords : Ageing Metabolism
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https://hal.archives-ouvertes.fr/hal-03448746
Contributor : Tom van Dooren Connect in order to contact the contributor
Submitted on : Friday, January 21, 2022 - 10:01:56 AM
Last modification on : Wednesday, May 11, 2022 - 3:19:49 AM
Long-term archiving on: : Friday, April 22, 2022 - 6:58:04 PM

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Sarah Séité, Mark Harrison, David Sillam-Dussès, Roland Lupoli, Tom van Dooren, et al.. Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite. Communications Biology, Nature Publishing Group, 2022, pp.44. ⟨10.1101/2021.05.10.443390⟩. ⟨hal-03448746⟩

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