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Synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion to controlled release of adenosine 5′‑monophosphate

Abstract : Herein, we propose the synthesis of a microspherical imprinted hydrogel meant for the controlled release of a nucleotide, adenosine 5'-monophosphate (5'-AMP). Indeed, molecularly imprinted polymers-based (MIPs) materials possess remarkable selective molecular recognition ability that mimicks biological systems. MIPs have been used in numerous applications and hold great promise for the vectorization and/or controlled release of therapeutics and cosmetics. But, the conception of imprinted hydrogels-based drug delivery systems that are able to release polar bioactive compounds is explored weakly. Herein, the synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion is detailed. Microspheres showed a large 5'-AMP loading capacity, around 300 mg·g-1, and a high binding capacity comparatively to the non-imprinted counterpart. The MIP had a thermo-responsive release behavior providing sustained release of adenosine 5'-monophosphate in an aqueous buffer simulating both human skin pH and temperature.
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Submitted on : Friday, October 22, 2021 - 4:55:21 PM
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Mohamed Ayari, Porkodi Kadhirvel, Patrick Favetta, Bernard Plano, Corinne Dejous, et al.. Synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion to controlled release of adenosine 5′‑monophosphate. Materials Science and Engineering: C, Elsevier, 2019, 101, pp.254-263. ⟨10.1016/j.msec.2019.03.102⟩. ⟨hal-02299722⟩

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